Undoubtedly, man is necessarily in loss.
The human being is utterly lost
Surely, the human is in a (state of) loss
Surely man is in loss
That truly the human/mankind (is) in (E) loss
that human beings are most definitely in loss
Indeed man is surely in a loss
Surely, man is ever in a state of loss
Indeed, man is at a loss (for he is losing his valuable lifetime)
Verily, a person (who is unmindful of God and higher values of his life) is pursuing a losing bargain
Verily! Man is in loss